An introduction to immunotoxicology by Jacques Descotes

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By Jacques Descotes

This article presents a concise and finished advent to key immunotoxicological concerns for all these drawn to, yet without previous wisdom of, this zone of toxicology. the 1st part explores the wellbeing and fitness results of immunotoxicity, specifically the adversarial results regarding chemically-induced immunosuppression and immunostimulation, allergy reactions and autoimmune ailments, with an outline of significant immunotoxicants. the second one half describes the newest equipment used to discover and evaluation, preclinically and clinically, the unforeseen immunotoxic results of xenobiotics. developments in imposing concepts and up to date alterations to the regulatory facets also are thought of. The 3rd part examines attainable destiny advancements, together with In Vitro tools, biomarkers of immunotixicity and probability evaluate.

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Available human data, although limited, nevertheless suggest that chemically-induced immunodepression can be associated with more frequent infections. Supportive evidence comes from patients with autoimmune diseases, such as rheumatoid patients treated with low-dose immunosuppressive treatments. Opportunistic infections have been described, even though uncommonly in rheumatoid patients (Segal and Sneller, 1997). , 1996). Very few data suggest that lymphomas can be more frequent in patients after chemical ‘immunodepressive’ exposures.

FELTEN, D. and COHEN, N. (1990) Interactions between the brain and the immune system. Annu. Rev. Pharmacol. , 30, 561–602. K. (1993) Nutrition and the immune system. Proc. Nutr. , 52, 77–84. J. (1995) Interactions between the nervous system and the immune system. Implications for psychopharmacology. E. , eds) pp. 719–731. New York: Raven Press. FRIER, S. (1990) The Neuroendocrine-Immune Network. Boca Raton: CRC Press. A. and TRAVERS, P. (1996) Immunobiology. 2nd edition. London: Current Biology Ltd, Garland Publishing.

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